In this discussion, we are going to focus on Hallmark 9: Reprogramming Energy Metabolism. This Hallmark is one of the two new emerging hallmarks published in the updated Hallmarks of Cancer publication. Uncontrolled and chronic cellular proliferation would naturally require more energy than what would be typically required for a normal cell. Otto Warburg (Warburg effect – aerobic glycolysis) was the first to observe abnormal energy metabolism in cancer cells. Recently, a new publication has highlighted the importance of altered energy metabolism in cancer and has crafted a separate set of hallmarks specific to cancer metabolism (The Emerging Hallmarks of Cancer Metabolism).
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