Structure–Based Design and Synthesis of 2-Benzylidene-benzofuran-3-ones as Flavopiridol Mimics
Introduction Flavopiridol, a well-established inhibitor of cyclin-dependent kinases (CDK’s), is currently undergoing clinical trials. The inhibition of CDK’s, which are involved in the cell division cycle, is a vital goal in anticancer agents and therefore having potent drugs which can selectively inhibit these is crucial. One of the aims is to synthesize 2-benzylidene-benzofuran-3-ones so that they are more potent at inhibiting some of the CDK’s […]