Directions: A mutation is a change in the genetic material (DNA). Sometimes a mutation will affect the expression of a gene in terms of the protein that is produced and sometimes it will not. For example, when you look at the mutation that causes Sickle Cell Anemia, you find a change in one nucleotide only. (As a reminder, your genetic material (DNA) is made of a long chain of nucleotides. A gene is a segment of DNA that encodes a specific protein or RNA.)
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